Title:
Mathematical Models of Genetic Control in Bacteria
Speaker:
Joseph M. Mahaffy, Department of Math Sciences, San Diego State University
Subject:
Quantitative Mathematical Modeling of Gene Regulatory Networks
Area:
Medicine
Type of school:
university
School name:
ohio state university
Country:
United States
Course language:
English
Course media:
Video
Course duration:
Contributor:
pbp
Comments:
Author: Joseph M. Mahaffy, Department of Math Sciences, San Diego State University
Title: Mathematical Models of Genetic Control in Bacteria
Presentation Materials: PPT
Streaming Video: Real Media
Regulation of metabolic pathways is very important in bacteria. Cells employ both positive and negative control mechanisms to maintain fairly stable amounts of key compounds, such as nutrients in the cytoplasm. Mathematical models have been developed using biochemical kinetics, which results in systems of differential equations. Multi-step processes can be modeled with a delay. These systems of delay-differential equations can be analyzed for their behavior. Several bacterial metabolic pathways and the control of the replication cycle in Escherichia coli are examined using some kinetic models. Analysis provides insight into the key regulatory elements in the pathway.
pbp